With several name changes, with a privileged location on the river Paraná (Paraná: PARA: sea; NA: relative; "Relative or Father of Waters").

Posadas was created in 1615 by Father Roque González, with a help from Itapúa chief.

... With a key position, was a communications site so then the port was the center of activities. At the "Bajada Vieja" (Old Town) and its vicinity had lodgings, place to have eat or just brothels, who served to the mensu ...

It links with the neighboring city of Garupá and together makes The Great Posadas. It also maintains strong links with the city of Encarnación, Paraguay, connected through the rail road bridge and San Roque Gonzalez de Santa Cruz that crosses over the Parana River, forming an important center of international trade.